منابع مشابه
Endothelial Dysfunction and Preeclampsia
1. Protogerou AD, Blacher J, Mavrikakis M, Lekakis J, Safar ME: Increased pulse pressure amplification in treated hypertensive subjects with metabolic syndrome. Am J Hypertens 2007;20:127–133. 2. Safar ME, Smulyan H: Hypertension in women. Am J Hypertens 2007;17:82–87. 3. Safar ME: Systolic blood pressure, pulse pressure and arterial stiffness as cardiovascular risk factors. Curr Opin Nephrol H...
متن کاملEndothelial cell dysfunction in preeclampsia.
Preeclampsia is a pregnancy-specific syndrome of hypertension and proteinuria and one of the leading causes of perinatal morbidity and mortality. The pathogenesis of preeclampsia, although not entirely clear, is typically abnormal placental implantation, followed by endothelial dysfunction with subsequently resulting vasospasm, coagulopathy, or changes in capillary permeability; this underscore...
متن کاملVascular adaptation in pregnancy and endothelial dysfunction in preeclampsia.
Maternal vascular adaptation to pregnancy is critically important to expand the capacity for blood flow through the uteroplacental unit to meet the needs of the developing fetus. Failure of the maternal vasculature to properly adapt can result in hypertensive disorders of pregnancy such as preeclampsia (PE). Herein, we review the endocrinology of maternal adaptation to pregnancy and contrast th...
متن کاملEndothelial dysfunction and preeclampsia: role of oxidative stress
Preeclampsia (PE) is an often fatal pathology characterized by hypertension and proteinuria at the 20th week of gestation that affects 5-10% of the pregnancies. The problem is particularly important in developing countries in where the incidence of hypertensive disorders of pregnancy is higher and maternal mortality rates are 20 times higher than those reported in developed countries. Risk fact...
متن کاملTherapeutically targeting mitochondrial redox signalling alleviates endothelial dysfunction in preeclampsia
Aberrant placentation generating placental oxidative stress is proposed to play a critical role in the pathophysiology of preeclampsia. Unfortunately, therapeutic trials of antioxidants have been uniformly disappointing. There is provisional evidence implicating mitochondrial dysfunction as a source of oxidative stress in preeclampsia. Here we provide evidence that mitochondrial reactive oxygen...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: American Journal of Hypertension
سال: 2007
ISSN: 0895-7061
DOI: 10.1016/j.amjhyper.2007.01.022